منابع مشابه
Dirty dancing--the FDA stumbles with the Chevron two-step: a response to professor Noah.
Professor Lars Noah deserves much credit for exposing some of the myriad ways in which the Food and Drug Administration (FDA) has consistently sought to expand its authority through questionable, and perhaps in some cases abusive, legal practices.1 As Professor Noah observes, there are signs that the federal courts’ century-long honeymoon with the FDA may be ending2—and perhaps the FDA never de...
متن کاملReinvestigation of the Two-Step Synthesis of Sevoflurane
Improvements in the two-step synthesis of 1,1,1,3,3,3-hexafluoro-2- (fluoromehoxy)propane (Sevoflurane) that result in the product cost reduction, safety level enhancement and positive environmental impacts are described. This process consists of chloromethylation reaction of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) followed by a halogen-exchange fluorination. This is the first synthesis of Sev...
متن کاملReinvestigation of the Two-Step Synthesis of Sevoflurane
Improvements in the two-step synthesis of 1,1,1,3,3,3-hexafluoro-2- (fluoromehoxy)propane (Sevoflurane) that result in the product cost reduction, safety level enhancement and positive environmental impacts are described. This process consists of chloromethylation reaction of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) followed by a halogen-exchange fluorination. This is the first synthesis of Sev...
متن کاملThe environmental two-step.
An important stage in macromolecular crystallography is that of phase extension and refinement when initial phase estimates are available from isomorphous replacement or anomalous scattering or other methods. For this purpose, an alternative method called the twin variables (TwiV) method has been proposed. The algorithm is based on alternately transferring the phase information between the twin...
متن کاملDancing eyes and dancing feet syndrome.
133 Introduction Opsoclonus-myoclonus is a rare neurological disorder characterised by intention tremor, unsteady gait, myoclonus and opsoclonus. Lethargy and irritability are also described. The abnormal eye movements are distinctive, being multidirectional and of high amplitude. Its recognition helps in the diagnosis of this clinical syndrome, the correct identification of which leads to the ...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2002
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm776